Seragon(美國(guó))

Seragon Pharmaceuticals

SeragonPharmaceuticalswww.seragonpharm.comSeragonPharmaceuticals前身是Aragon的乳癌藥物開(kāi)發(fā)部門(mén)SeragonPharmaceuticals’orallyactiveselectiveestrogenreceptordegraders(SERDs)representapotentialnewtreatmentforpr ogressivemetastaticbreastcancerthatmaycircumventtheproblemofresistancetoanti-hormonaltherapies.SERDsareestrogenreceptorantagoniststhatalsoinduceaconformationalchangethatresultsinthedegradationofthereceptor.SeragonhasidentifiedmultipleSERDsthathavepharmacokineticprofilessufficienttodrivearobusttherapeuticresponseandresultindegradationofthereceptorandanti-tumoractivity.Thenovelprofileofthesepotent,orallybioavailable,nonsteroidalagentsmayresultingreaterefficacyandresponseratesinpatientswithhormone-refractorybreastcancercomparedtootherdrugsindevelopment.Seragon’smostadvancedleadsinducetumorregressionsinbothtamoxifensensitiveandtamoxifenresi